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Generic Name : Sitagliptin + Metformin Hcl.

Brand Name : Janumet

Manufacturer Name : MSD

Product Code : CRX 289

Delivery Days : 10 to 15 working days

Strength : 500 MG

Packaging : Tablet/s (Blister Packing)

Prescribed For : Type 2 Diabetes Mellitus



Janumet 50mg/500mg

Janumet 50mg/500mg is a prescription medication that combines two active ingredients, sitagliptin and metformin, in a single tablet. This combination is designed to provide effective management of type 2 diabetes mellitus, a chronic condition characterized by elevated blood sugar levels. In this comprehensive description, we will explore the components of Janumet, its mechanism of action, therapeutic effects, dosage, potential side effects, and other relevant information.




Janumet 50mg/500mg contains two key ingredients: sitagliptin and metformin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, while metformin belongs to the class of biguanides. Each tablet comprises 50mg of sitagliptin and 500mg of metformin hydrochloride. These compounds work synergistically to address different aspects of glucose metabolism.


Mechanism of Action:-

Sitagliptin exerts its effect by inhibiting DPP-4, an enzyme that degrades incretin hormones. Incretins play a crucial role in regulating blood sugar levels by stimulating the release of insulin and suppressing the production of glucagon. By inhibiting DPP-4, sitagliptin prolongs the action of incretins, leading to increased insulin secretion and decreased glucagon levels.

Metformin, on the other hand, primarily works by reducing glucose production in the liver and enhancing the body's sensitivity to insulin. It also improves the uptake of glucose by peripheral tissues, such as muscles. The combined action of sitagliptin and metformin helps control fasting and postprandial blood glucose levels.


Therapeutic Effects:-

Janumet 50mg/500mg is prescribed to individuals with type 2 diabetes to achieve better glycemic control. The medication helps lower blood sugar levels by addressing insulin resistance, reducing glucose production in the liver, and enhancing insulin secretion. By regulating glucose metabolism, Janumet aims to prevent complications associated with uncontrolled diabetes, such as cardiovascular disease, neuropathy, and nephropathy.

The combination of sitagliptin and metformin provides a comprehensive approach to managing diabetes, targeting multiple pathways involved in glucose regulation. This dual action is particularly beneficial for individuals whose diabetes cannot be effectively controlled with a single medication.


Dosage and Administration:-

The recommended dosage of Janumet 50mg/500mg is typically determined by a healthcare professional based on the patient's individual needs and response to treatment. It is usually taken twice daily with meals to ensure optimal absorption and minimize gastrointestinal side effects associated with metformin.

Patients are advised to follow the prescribed dosage and administration instructions meticulously. Skipping doses or altering the regimen without consulting a healthcare provider may compromise the effectiveness of treatment.


Side Effects:-

Like any medication, Janumet 50mg/500mg may cause side effects. Common side effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and abdominal discomfort. These side effects are often transient and may diminish as the body adjusts to the medication.

In rare cases, more serious side effects may occur, including lactic acidosis, a rare but potentially life-threatening condition associated with metformin use. Symptoms of lactic acidosis include muscle pain, respiratory distress, and abdominal discomfort. Patients experiencing these symptoms should seek immediate medical attention.

It is crucial for individuals taking Janumet to communicate any unusual or persistent side effects to their healthcare provider. Regular monitoring and follow-up appointments are essential to ensure the medication's safety and efficacy.


Precautions and Contraindications:-

Janumet is not suitable for everyone, and certain precautions should be taken. It is contraindicated in individuals with a history of hypersensitivity to any of its components, as well as those with severe renal impairment or end-stage renal disease. Before initiating Janumet therapy, healthcare providers should assess renal function and consider dosage adjustments in patients with impaired kidney function.

Pregnant and breastfeeding women should consult their healthcare provider before using Janumet, as the safety of the medication in these populations is not well-established.



In summary, Janumet 50mg/500mg is a combination medication designed to address the complex nature of type 2 diabetes mellitus. By combining sitagliptin and metformin, it offers a dual approach to managing blood glucose levels, providing a valuable option for individuals struggling to achieve optimal control with a single-agent therapy. While effective, it is essential for patients to work closely with their healthcare providers, adhere to prescribed dosages, and promptly report any side effects for a safe and successful diabetes management journey.



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